The Safest and Richest Midsize Midwest Cities in 2026

It’s fascinating to see how eight mid-sized Midwest cities are combining high median incomes—over $100,000—with home values ranging from $376K to $610K and living costs between $48,790 and $67,194. Not only do these cities offer strong economic profiles, but they’re also recognized for having low crime rates and populations between 75,000 and 500,000. As someone who’s guided clients through residential markets in Maryland, I always appreciate learning how different regions balance affordability, safety, and quality of life—whether you’re considering a move, an investment, or simply curious about how Maryland compares to other thriving communities.